What medications should I avoid taking with paroxetine and venlafaxine?

Paroxetine and venlafaxine can interact with other drugs that increase serotonin levels or activity in the body, such as antidepressants (SSRIs, SNRIs, TCAs, and MAOIs) and numerous other drug classes.

Paroxetine and venlafaxine can increase the risk of bleeding when used with other drugs that increase bleeding risk, which can include blood thinners, other drugs that affect platelet function, and NSAIDs. If you are a regular user of these medications, please discuss with your provider.

This list is not exhaustive, and patients should inform providers of all medications and supplements they are taking to determine if there are any concerning drug interactions.

Please see the full Prescribing Information for additional information regarding paroxetine or venlafaxine.

This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your healthcare provider. 

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