In general, it is recommended to take 2,000 mg of valacyclovir by mouth at the earliest sign of an oral outbreak. Then, 12 hours later, take another 2,000 mg of valacyclovir as the second and final dose. The second dose can be taken sooner than 12 hours but never before 6 hours have passed. Make sure to stay hydrated by drinking fluids throughout the day.
The medication is only approved for two doses in an outbreak and there is no evidence in studies to advise the use of medication once lesions have appeared.
For those who are infected with HIV, the recommended dose is 1 gram every 12 hours for 5–10 days. Please see the full Prescribing Information here.
This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your healthcare provider.