Many women have urinary symptoms associated with menopause in addition to vaginal dryness. These include frequent urination, urinary urgency, waking up frequently in the middle of the night to urinate (nocturia), discomfort during urination (dysuria), and recurrent urinary tract infections (UTIs). The collection of these symptoms along with vaginal dryness and irritation are often called genitourinary syndrome of menopause (GSM). Low dose vaginal estrogen is an effective treatment for the symptoms of GSM and is considered safer than systemic estrogen.
Vaginal estradiol is not appropriate for everyone. To learn more about who should not use vaginal estradiol cream and the side effects that it may cause, including the boxed warning regarding endometrial cancer, cardiac events, and dementia, please see the important safety information for vaginal estradiol.