Due to concerns about blood clots, stroke, and breast cancer from the WHI study, many women are not candidates for oral or systemic hormone replacement (estrogen with or without progesterone) therapy. Many others are concerned about the risks associated with systemic hormone replacement therapy. Fortunately, low dose vaginal estrogen is an available effective treatment for vaginal dryness and is considered safer than systemic estrogen therapy.
Vaginal estradiol is not appropriate for everyone. To learn more about who should not use vaginal estradiol cream and the side effects that it may cause, including the boxed warning regarding endometrial cancer, cardiac events, and dementia, please see, please see important safety information.