What Are The Most Common Side Effects of Vaginal Estradiol?

The Physician Digital Reference (PDR) lists the following common side effects for oral estradiol:

  • Headache, back pain
  • Weight gain
  • Skin irritation, itching
  • Diarrhea, nausea, abdominal pain
  • Period cramps, breakthrough bleeding
  • Pain in the breasts
  • Nausea
  • Abdominal pain


These are not all of the potential side effects of vaginal estradiol. To learn more about who should not use vaginal estradiol cream and the side effects that it may cause, including the boxed warning regarding endometrial cancer, cardiac events, and dementia, please see important safety information

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