Are There Any Conditions That Could Make Estradiol Vaginal Cream an Inappropriate Treatment for Me?

If you have any of the following, vaginal estradiol is not appropriate for you:

 

  • Undiagnosed abnormal genital bleeding
  • Known, suspected, or history of cancer of the breast
  • Known or suspected neoplasia (cancer or abnormal cells) that are affected by estrogen, now or at any time in the past
  • Any blood clotting problem (e.g., DVT—Deep Vein Thrombosis, which is a blood clot in any vein in the body; PE—Pulmonary Embolism, which is a blood clot in the lung) now or at any time in the past
  • Thromboembolic disease (e.g., stroke, heart attack) now or at any time in the past
  • Known allergy reaction of any severity to estradiol vaginal cream
  • Known liver disease from any cause, or a decrease in liver function
  • Known protein C, protein S, or antithrombin deficiency, or other known disorders that affect blood clotting
  • Known or suspected pregnancy, or breastfeeding  

Vaginal estradiol is not appropriate for everyone. To learn more about who should not use vaginal estradiol cream and the side effects that it may cause, including the boxed warning regarding endometrial cancer, cardiac events, and dementia, please see, please see important safety information.

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