What Medications Can Interact with Melatonin?

The medications below may cause drug interactions with melatonin. You should talk to your primary healthcare professional about using melatonin if you take any of these medications.

 

  • Birth control pills (may increase melatonin levels)
  • Caffeine (may increase melatonin levels)
  • Fluvoxamine/Luvox (may increase the effect and side effects of melatonin)
  • Flumazenil/Romazicon (decrease effectiveness of melatonin)
  • Medications that are broken down by the liver, because melatonin may decrease how quickly the liver breaks down some medication. Some medications that are broken down by the liver include, but are not limited to:
    • acetaminophen (Tylenol), amitriptyline (Elavil), clopidogrel (Plavix), clozapine (Clozaril), diazepam (Valium), estradiol, olanzapine (Zyprexa), ondansetron (Zofran), propranolol (Inderal), ropinirole (Requip), tacrine (Cognex), theophylline, verapamil (Calan, Covera-HS, Isoptin, Verelan), warfarin (Coumadin), carisoprodol (Soma), citalopram (Celexa), lansoprazole (Prevacid), omeprazole (Prilosec), and phenytoin (Dilantin)
  • Medications for high blood pressure (melatonin can raise blood pressure in people taking certain medication for high blood pressure). Some medications for high blood pressure include, but are not limited to:
    • captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix)
  • Medications that lower the seizure threshold (melatonin may increase the frequency of seizures in some people). Some medications that lower the seizure threshold include, but are not limited to:
    • anesthetics, mexiletine, amphotericin, penicillin, cephalosporins, bupropion, imipenem,, antidepressants, antihistamines, cyclosporine, fentanyl and narcotics, methylphenidate, and theophylline
  • Medications that are anticoagulants or antiplatelet (melatonin can slow down blood clotting). Some medications that are in this category include, but not limited to:
    • aspirin, clopidogrel, diclofenac, ibuprofen, naproxen, dalteparin, enoxaparin, heparin, warfarin, rivaroxaban (Xarelto) , apixaban (Eliquis), dabigatran (Pradaxa)
  • Medications that prevent seizures (melatonin may decrease their effectiveness). Anticonvulsant medications include, but not limited to:
    • phenobarbital, primidone (Mysoline), valproic acid (Depakene), gabapentin (Neurontin), carbamazepine (Tegretol), phenytoin (Dilantin)
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