Who Should Never Take Venlafaxine for Hot Flashes?

Venlafaxine is not appropriate for everyone—you and your Rory-affiliated provider will decide if venlafaxine is an appropriate treatment for your hot flashes. Do not use venlafaxine if any of the following apply to you.

 

  • History of suicidal thoughts or attempts unless under the direction of a psychiatrist
  • History of self-injurious behavior unless under the direction of a psychiatrist
  • History of bipolar disorder unless under the direction of a psychiatrist
  • History of manic or depressive episodes unless under the direction of a psychiatrist
  • History of serotonin syndrome
  • Patients taking an SNRI for another indication like depression or anxiety. (e.g. Cymbalta, Effexor, Fetzima, Pristiq, venlafaxine, desvenlafaxine, duloxetine, levomilnacipran)
  • People taking MAOIs or who have taken MAOIs in the previous 2 weeks.
  • People with a history of long QT syndrome or who are taking drugs that lengthen the QT interval.
  • People with moderate-severe liver disease. Even people with mild liver disease may require lower doses.
  • People with moderate-severe kidney disease. Even people with mild kidney disease may require lower doses.
  • People who are pregnant or nursing.
  • Children under the age of 18.
  • People with uncontrolled high blood pressure.
  • People with bleeding disorders, or who are taking medications that increase their risks of bleeding, should discuss this with their doctor before taking venlafaxine. In most cases, an alternative treatment strategy will be used.

For more information about the safety of venlafaxine, please see important safety information.

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