Who Should Not Take PDE5 Inhibitors (like Sildenafil) for Premature Ejaculation (PE)

Anyone with any of the following should not take PDE5 inhibitors (like sildenafil) for PE:


  1. Patients who take nitrates or even carry nitrates in case they’re needed in response to chest pain
  2. Patients with a history of tinnitus
  3. Allergy or negative reaction to sildenafil or other phosphodiesterase 5 inhibitors (PDE5i) under different names or any components (e.g. Viagra, Cialis, Levitra, Staxxyn, Stendra, Revatio, tadalafil, vardenafil, avanafil)
  4. Patients who feel “winded” or too weak or tired to walk up 2 flights of stairs relatively briskly
  5. Patients who have unstable heart disease or have been told they are not healthy enough for sex
  6. Patients who have nonarteritic anterior ischemic optic neuropathy (NAION) or retinitis pigmentosa
  7. Patients with idiopathic hypertrophic subaortic stenosis (IHSS).
  8. Patients with very low blood pressure


Based on your medical history and current medications list, your provider may determine that there are safer treatment choices for PE than PDE5i. For a full list of contraindications to sildenafil please see the Prescriber’s Digital Reference (PDR).


This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your doctor.  

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