What is the Recommended Treatment for Oral Herpes with Valacyclovir

To abort an outbreak of herpes on the lips or mouth the recommendation is that the patient should take 2 grams (2,000 mg) of Valacyclovir at the first sign or symptom of lesions and a second dose of 2 grams (2,000 mg) 12 hours later. The second dose should not be taken within 6 hours of the first. Those are the only doses recommended, but patients sometimes take another dose or two of just 1 gram if they continue to have symptoms, or if a mild outbreak follows.

The Prescriber’s Digital Reference (PDR) states that for HIV-infected patients, 1 gram (1000 mg) be taken every 12 hours for 5 to 10 days. Despite what some patients do when having continued symptoms the PDR states, “there are no data supporting the effectiveness of beginning treatment after the development of clinical signs of a cold sore (e.g., papule, vesicle, or ulcer).”


This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your doctor.  

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