Are There Any Drugs That Interact with SSRIs (like Sertraline)?

If you are taking any medications to treat psychiatric problems, you should not be prescribed SSRIs to treat PE.

One category of antidepressants called monoamine oxidase inhibitors (MAOi) can interact with SSRI and cause a life-threatening medical problem. These medications include, but are not limited to, isocarboxazid (Marplan), selegiline (Emsam), phenlezine (Nardil), and tranycypromoine (Parnate).

An antibiotic called linezolid (Zyvox) acts like an MAOi and is also strictly prohibited for patients taking SSRIs.

Many other drugs interact with SSRIs, including:

    1. Serotonin Norepinephrine Reuptake Inhibitors (SNRIs): This is another class of commonly used antidepressants.


  • Tricyclic antidepressants (TCAs): This is another class of antidepressants often used  for certain types of chronic pain.


    1. Anticoagulants and antiplatelet agents: Any drug that increases the risk of bleeding has a greater risk of bleeding when taken with an SSRI like sertraline. There are many drugs in this category. Some examples include Coumadin (warfarin), Pradaxa (dabigatran), Xarelto (rivaroxaban), Savaysa (edoxaban), aspirin, Plavix (clopidogrel), Brilinita (tecagrelor), Effiant (prasugrel), and others.


  • Any drug that increases the QT interval: These drugs can cause a life threatening arrhythmia and the risk for this may be greater when taken together with sertraline.


The above list is not comprehensive. Always tell your doctor what medicines you are taking before starting a new medication. For a complete list of drugs that interact with sertraline, please see the Prescriber’s Digital Reference (PDR).


This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your doctor.  

Was this article helpful?
0 out of 0 found this helpful



Article is closed for comments.