Who Should Not Take SSRIs (like sertraline) for Premature Ejaculation (PE)?

Anyone with any of the  following should not take SSRIs (like sertraline) for PE:

  1. History of suicidal thoughts or attempts
  2. History of self-injurious behavior
  3. History of bipolar disorder
  4. History of manic or depressive episodes
  5. History of serotonin syndrome
  6. Patients taking an SSRI for another indication like depression or anxiety. (e.g. Lexapro, Celaxo, Paxil, Prozac, Viibryd, Zoloft, paroxetine, fluoxetine, citalopram, escitalopram)
  7. People taking MAOIs or who have taken MAOIs in the previous 2 weeks.
  8. People with a history of long QT syndrome or who are taking drugs that lengthen the QT interval.
  9. People with moderate-severe liver disease. People with mild liver disease may require reduced doses of sertraline
  10. Children under the age of 18.
  11. People with bleeding disorders, or who are taking medications that increase their risks of bleeding, should discuss this with their doctor before taking sertraline. In most cases, an alternative treatment strategy should be used.

For a full list of contraindications to sertraline please see the Prescriber’s Digital Reference (PDR).


This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your doctor.  

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