What Are the Most Common Side Effects for PDE5 Inhibitors (like Sildenafil)?

The most common side effects of PDE5 inhibitors are:

  • Headache
  • Facial flushing
  • Nasal congestion
  • Dyspepsia
  • Visual disturbances

Most of these side effects will go away with continued use of the medication and most men tolerate PDE5 inhibitors well. There is also the possibility that you may experience a side effect with one PDE5 inhibitor (like sildenafil), but not with another PDE5 inhibitor (like tadalafil). Sometimes switching medications or decreasing  the dose can alleviate the side effect. There are many other potential side effects. For a complete list of side effects please see the PDR.


This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your doctor.  

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