What are some common side effects of vaginal estradiol?

Most patients tolerate vaginal estradiol well, but as with any medication, vaginal estradiol can have side effects including headache, back pain, weight gain, skin irritation or itching, diarrhea, nausea, abdominal pain, period cramps, vaginal bleeding, and/or pain in the breasts.

Vaginal estradiol is not appropriate for everyone. It can cause serious drug interactions and side effects that you should understand before using it for vaginal dryness. Please discuss side effects with your provider if you have any concerns.

Please also see the full Prescribing Information, including the BOXED WARNING, for complete safety information

This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your healthcare provider.  

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