Bupropion can be taken with food if it causes an upset stomach. There are a few other general words of advice concerning bupropion (read the package insert for a complete list). The evening dose should not be taken at bedtime if it causes insomnia. Do not break the medication. Keep your medication between 68 and 77 degrees F. Keep it stored in a cool, dry, dark place with the lid tightly sealed and away from children. Throw it out if it is beyond the expiration date.