No. You should not use bupropion while you are pregnant. Most studies of bupropion during pregnancy “indicate no overall increased risk of congenital malformations. In addition, no increased risk of cardiovascular malformations during first trimester exposure to bupropion has been observed.” However, studies looking at certain heart defects in infants born to mothers who used bupropion in the first trimester have been “inconsistent.”
Pregnant smokers are encouraged to try everything short of using a medication or other aids before making the difficult choice between the benefits of using a medication to quit smoking versus the risk any medication might pose to their unborn child. Also, while not reported as a problem with bupropion, other antidepressants have been noted to cause withdrawal or even toxicity to newborns when taken during the 3rd trimester.
This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your doctor.