Maybe. The active ingredient in Zyban, bupropion hydrochloride, is the same active ingredient in the antidepressant Wellbutrin. Many people feel depressed when they quit smoking. This can be due to the direct effects of nicotine withdrawal, but it can also be caused by the loss associated with cutting out a pleasurable habit from your daily life. Taking bupropion to help you quit smoking may help with these feelings of depression.