What are Some common Medications that Interact with Bupropion (Generic for Zyban)?

There are many medications that interact with bupropion. This list is not comprehensive. Make sure to inform your doctor of all prescription and over the counter medications before you start taking bupropion. The Physician’s Desk Reference (PDR) provides a comprehensive list. Some common drugs that interact with bupropion are:


  • Antidepressants, including medicines containing bupropion
  • Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine, Nardil, tranylcypromine, Parnate, isocarboxazid, Marplan, selegiline, Emsam)
  • Some HIV medications including Ritonavir (Norvir), lopinavir (Kaletra), and efavirenz (Atripla)
  • Medications that lower the seizure threshold including:
    • Antipsychotics
    • Antidepressants
    • Theophylline
    • Systemic corticosteroids (e.g., prednisone, hydrocortisone, dexamethasone, triamcinolone, etc.)


This represents only a small portion of the medications that may interact, which is why every medication you take, have taken in the past 2 weeks, or plan to take even up to 2 weeks once you complete your course of therapy, should be reviewed with your healthcare provider.


This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your doctor.  

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