Answer: Bupropion cannot be used with medications called Monoamine Oxidase Inhibitors (MAOIs)—examples include, rasagiline (Azilect), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate). In fact, bupropion cannot be used in anyone who used an MAOI two weeks before starting bupropion or who even may need it two weeks after stopping bupropion. The interaction between bupropion and MAOIs can be very dangerous and life threatening. Before starting bupropion (or any medication), it is essential that you inform your physician if you are currently taking MAOIs or have taken them in the past two weeks.
This information is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment, and should never be relied upon for specific medical advice. If you have any questions or concerns, please talk to your doctor.